3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid

Name	propargyl-PEG3-Acid
Synonyms	Alkyne-PEG3-COOH PROPARGYL-PEG3-COOH propargyl-PEG3-Acid Propyne-PEG2-CH2CH2COOH Propargyl-PEG2-CH2CH2COOH Propargyl-PEG4-(CH2)3-acid 3-{2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy}propanoic acid 3-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid
CAS	1347760-82-0

Molecular Formula	C10H16O5
Molar Mass	216.23
Storage Condition	-20°C
In vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

biological activity	Propargyl-PEG3-acid is a non-cleavable ADC linker with 3 unit PEG, and is also a PEG-based PROTAC linker, which can be used to synthesize 6-OHDA-PEG3-yne. 6-OHDA-PEG3-yne contains 6-OHDA (HY-B1081, HY-B1081A) and Propargyl-PEG3-acid.
target	PEGs Non-cleavable
in vitro study	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Last Update：2024-04-10 22:41:03

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